The Samplix Xdrop system solves traditional laboratory workflow delays by replacing slow, resource-intensive bulk assays and microtiter plate methods with a high-throughput, double-emulsion droplet microfluidic platform. Standard laboratory assays often stall due to prolonged incubation times required for signals to build up, low-throughput single-cell screening, or bias in targeted sequencing. Samplix Xdrop eliminates these bottlenecks by packaging single cells or long DNA fragments into uniform, picoliter-volume droplets that function as independent micro-reactors. The Core Technology Behind Accelerating Workflows
Xdrop eliminates long experimental wait times through a specialized, streamlined double-emulsion droplet technology.
Accelerated Signal Buildup: By encapsulating single cells into highly stable, ~100-picoliter droplets (using cartridges like the Xdrop DE50), the microscopic reaction space forces cell secretions to accumulate much faster. This dramatically cuts down incubation times.
Massive Parallel Processing: The system can process up to 8 samples in parallel, generating roughly 150,000 single-cell assays per sample in just 8 minutes.
Leveraging Existing Instruments: Unlike conventional custom droplet workflows that demand highly specialized infrastructure, Xdrop double-emulsion (water-in-oil-in-water) droplets are fully compatible with standard flow cytometers, cell sorters, and imaging systems already found in most labs. This eliminates the delay of purchasing or learning complex new machinery. Resolving Specific Delays Across Scientific Domains 1. Cell Therapy and Single-Cell Functional Assays
Traditional functional screenings (such as checking for NK cell or antibody secretions) usually rely on bulk assays that blur individual cell performance or slow microtiter plates.
The Xdrop Fix: Cells stay highly viable (~90%) inside the stable droplets and can be placed right into a standard CO2cap C cap O sub 2
incubator. Researchers can perform rapid, high-purity phenotype sorting and immediately move positive cells into downstream single-cell RNA sequencing (scRNA-seq) or clonal expansion without waiting days to see a signal. 2. Genomic Sequencing and Targeted DNA Enrichment
When validating gene edits, CRISPR outcomes, or viral integrations, standard PCR amplification workflows face delays due to competitive amplification or an inability to capture long fragments without creating chimeric molecules. How the double-emulsion droplet could … – Samplix
The results for IFN-γ secretion from non-activated and IL-2-activated NK cells incubated for 3 hours in MEM α in bulk (bulk assay)
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